Based on the fit and person-in-situation theory, this study investigated the effect of each variable on retention tendency to propose a more comprehensive fit research framework. Taking the semiconductor manufacturing industry in Taiwan as the research population, this study surveyed R&D personnel in 15 manufacturers. A total of 300 questionnaires were sent out, with the matched samples were valid for a response rate of 72%. To all R&D personnel, the findings of this study indicate that: i. Person-organization fit is positively related to retention tendency. ii. Person-group fit is positively related to retention tendency. iii. Person-job fit is positively related to retention tendency. iv. Person-supervisor fit is positively related to retention tendency. v. Under the R&D personnel’s multidimensional fits, the person-organization, person-job, and person-supervisor fits have significantly positive effects on the retention tendency, but person-group fit has no significant effect. This study proposed some practical management implications based on the findings.