TAF PUBLISHING

Obesity has been rising as a major public health challenge. The obesity epidemic is more in middle-aged women in urban areas than those in rural areas. The metabolic disease has characteristic features like a higher prevalence of abdominal obesity in South Asians than white Caucasians. Because of the occurrence of metabolic syndrome at a lower range of Body Mass Index (BMI) and it is proposed that cut-offs for both measures of obesity should be changed to reach a new set point for overweight BMI 23-24.9kg/m2 and ≥25 kg/m2 for obesity for South Asians. The strength and direction of energy balance (energy flux and body weight) and type 2 diabetes (T2D) development have not been adequately investigated. In this study, nearly 2000 middle-aged Bangladeshi women were taken as a study population who had not suffered from diabetes. These women had to face interviews at the initial phase, and finally, repeated investigation was done regularly to collect information on their metabolic risk factors. Throughout 3.6 years follow-up, 850 new cases of T2D were documented. During follow-up, 850 new cases of T2D were documented. Energy Intake (EI) was associated with increased risk, and energy expenditure with Physical Activity (PA) was associated with weight change and decreased risk of T2D. In our population, we found women tend to develop T2D who are less active with higher EI than those more active with lower EI. We also observed the association was more evident among overweight and obese women (BMI≥25 kg/m2). These follow-up studies suggest that energy balance plays a dominant role in the development of weight regulation, and this effect may be modified by BMI. Bodyweight regulation is a complex collection and genetic variable that control energy intake and expenditure. Further study of this concept may help to achieve a healthy weight.