TAF PUBLISHING

Hand eczema is a common dermatologic condition that has a poor response to conventional therapies. Calcipotriol, a topical vitamin D analog, has been approved to treat psoriasis and was reported to achieve a beneficial effect in the treatment of many other inflammatory diseases. This study aims to assess the efficacy and safety of calcium ointment in treating chronic hand eczema. Six patients were treated with calcipotriol twice daily for two weeks. HECSI and the patient’s self-assessment evaluated the efficacy. Any adverse reaction was recorded during the experiment. The result revealed a statistical improvement of mean HECSI compared to the baseline after two weeks of treatment (p = 0.029). The only mild local side effect was observed. By subjects’ evaluation, all the patients showed an improvement of clinical severity. The result can be implied that topical vitamin D analog is safe and can be an alternative treatment for chronic hand eczema.