TAF PUBLISHING

Preeclampsia is a condition with diastol blood pressure become ≥ 90 mmHg and proteinuria in gestation more than 20 weeks. Maternal mortality in Indonesia was caused by preeclampsia as the number 2 cause. Preeclampsia is signed by endothelial dysfunction. Prevention of preeclampsia had not been developed yet. Exercise is an activity that can induce endogen anti-inflammation and antioxidants. So, it can be used to prevent the same process in preeclampsia. This research analyzed the difference of bodyweight and body length in endothelial dysfunction pregnant Mus musculus, which was given mild, regular exercise and without exercise. This research was true experimental with post-test only with control group design, consisting of 2 steps. Step 1 to know the dose of anti QA2, and step 2 to know the effect of mild, regular exercise on the body weight and bodylength of the fetus. Step 2 consisted of 4 groups (K1 for control normal pregnant, K2 for injected anti-QA2 as endothelial dysfunction model pregnant, K3 for injected anti-QA2 as endothelial dysfunction model pregnant with mild, regular exercise since early pregnancy, K4 for injected anti-QA2 as endothelial dysfunction model pregnant with mild, regular exercise since one week before pregnant). The number of Mus musculus was 6/group based on the Federer formula. Determination of anti QA2 dose to induce endothelial dysfunction was done by using some doses and examining vasoconstriction of the vessel in the uterus by HE examination. The dose that caused optimal vasoconstriction was 50 ng. The result showed there was no significant difference in body weight among all groups (p = 0.432), but bodyweight in K4 (0.9102 grams) was more than K2 (0.8388 grams). There was no significant difference in body length also among all of the groups (p = 0.662), but body length in K4 (2.1897 cm) was longer than K2 (2.0939 cm). There were no significant differences in bodyweight and body length in endothelial dysfunction pregnant Mus musculus as preeclampsia induction, which was given mild, regular exercise and without exercise.